Viagra (Sildenafil)

Viagra

Viagra Application:

Erectile Dysfunction, Male Enhancement, Erection, Impotence

Viagra Generic names:

Sildenafil citrate, Viagra, Generic Viagra, Kamagra, revatio , phrodil, Edegra, Erasmo, Penegra, Supra, Zwagra, Ygra

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Your Viagra Instruction for Use

What is Viagra?

Viagra is the world’s first oral pharmaceutical product, which is recognized effective for most men having problems with erection.

How Does Viagra Work?

The main mechanism of this ED drug action is a significant increase in blood flow to the penis, which contributes to natural erection appearance. Viagra has a positive effect only on natural mechanisms of erection.

This medication is not a general stimulant that increases male libido. It does not cause the appearance of sexual desire. The action of “magic” tablets is based only on the local increase in blood flow to the penile cavernous body, which encourages erection.

What is Viagra Used for?

Viagra is used for erectile dysfunction treatment manifested by an inability to reach or keep erection enough to a sexual intercourse with appropriate final – ejaculation. Viagra pills are efficient only in case of sexual stimulation. The active ingredient is sildenafil citrate available in dosage 25, 50 and 100 mg. You’d better consult a doctor to determine what dosage is suitable for you.

Contraindications

Viagra is used in people undergoing a long-lasting therapy of nitric oxide donators, organic nitrates or nitrites in any form because Viagra improves the hypotensive effect of this exact medications.
Viagra Contraindications_

  • children and adolescents under 18;
  • women;
  • hypersensitivity to sildenafil or to any components of the drug.

Viagra from Canadian Pharmacy should be utilized with caution in case of the following list of disorders:

  • penile anatomical traumas (angulation, cavernous fibrosis or Peyronie’s disease);
  • predisposition to priapism (such as sickle cell anemia, multiple myeloma, leukemia, thrombocytopenia);
  • predisposition to hemorrhages;
  • stomach and duodenum peptic ulcer exacerbation;
  • pigment retinitis of the hereditary base;
  • cardiac failure;
  • uncontrolled angina pectoris;
  • the last 6 months myocardial infarction;
  • blood stroke;
  • severe life-threatening arrhythmias;
  • increased or decreased arterial blood pressure.

Dosage

It is taken orally. For most patients, Viagra recommended dose is 50 mg, approximately 1 hour before sexual intercourse. Regarding effectiveness and tolerability, the dose can be leveled up to 100 mg or down to 25 mg. The maximum recommended dose is 100 mg. The maximum recommended frequency of application is 1 time/day. In elderly patients, dose adjustment is not required.

Viagra effect lasts for up to 5 hours.

Side Effects

ViagraThe most commonly observed Viagra side effects were a headache and “hot flashes”. Such adverse reactions are usually mild or moderate and disappear by themselves. Clinical trials have recorded that certain side effects frequency enhances when doses are increased.

Visual Organs:

  • often – blurry vision, visual disorders, cyanopsia;
  • infrequently – eyes pain, photophobia, photopsia, chromatic vision, reddening of eyes / ocular injection, change in light perception brightness, mydriasis, conjunctivitis, eye hemorrhage, cataracts, lacrimal apparatus malfunction;
  • rarely – eyelids and adjacent tissues edema, dry eyes, rainbow vision, increased eye fatigue, a vision of objects in yellow color (xanthopsia), a vision of objects in red (erythropsia), conjunctival hyperemia, conjunctival irritation, discomfort in eyes;
  • frequency unknown – non-arteritic anterior ischaemic optic neuropathy, retinal vein occlusion, retinal vein occlusion, diplopia, temporary loss of vision or visual acuity, increased intraocular pressure, retinal edema, retinal vascular disease, vitreous detachment / vitreous traction.

Hearing Organs: infrequent – sudden decrease or loss of hearing, tinnitus, ears pain.

Cardiovascular System:

  • often – “hot flashes”;
  • infrequent – tachycardia, palpitations, decreased blood pressure, increased heart rate, unstable angina, AV-blockade, myocardial ischemia, cerebral vascular thrombosis, cardiac arrest, cardiac failure, abnormalities in ECG, cardiomyopathy;
  • rarely – atrial fibrillation.

Hematopoiesis System: infrequently – anemia, leukopenia.

Metabolism and Nutrition: infrequently – thirst, swelling, gout, poorly controlled diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemia, hypernatremia.

Respiratory System:

  • often – stuffiness in nose;
  • infrequently – nasal hemorrhage, rhinitis, asthma, short breathing, sore throat, pharyngitis, sinusitis, bronchitis, leveled up sputum volume, coughing;
  • rarely – throat tightness, nasal cavity mucous membrane dryness, nasal mucosa swelling.

Digestive System:

  • often – nausea, indigestion;
  • infrequently – gastroesophageal reflux disease, vomiting, abdominal pain, dry mouth, tongue inflammation, gum inflammation, colitis, deglutitive problem, gastritis, gastroenteritis, esophagitis, stomatitis, deviation of liver function tests from normal, rectal bleeding;
  • rarely – hypoaesthesia oral.

Musculoskeletal System:

  • often – back pain;
  • infrequently – myalgia, extremities pain, arthritis, arthrosis, ligament rupture, peritendinitis, bone pain, myasthenia gravis.

Genitourinary System:

  • infrequently – cystitis, nocturia, breast enlargement, urinary incontinence, hematuria, ejaculatory disorder, genitals edema, anorgasmia, hematospermia, penile tissues damage;
  • rarely – prolonged erection and/or priapism.

Central and Peripheral Nervous System:

  • very often – headache;
  • often – dizziness;
  • infrequently – drowsiness, migraine, ataxia, hypertonus, neuralgia, neuropathy, paresthesia, tremor, faintness, depression, sleeplessness, unusual dreams, increased reflexes, hypoesthesia;
  • rarely – convulsions with repeated cases, fainting.

Skin and Subcutaneous Tissues:

  • infrequently – skin rash, hives, herpes simplex, intense itching, sweating, skin ulceration, contact dermatitis, exfoliative dermatitis;
  • frequency is unknown – Stevens-Johnson syndrome, toxic epidermal necrolysis.

Other:

  • infrequent – fever, facial swelling, photosensitivity reactions, shock, asthenia, fatigue, pain of different locations, chills, accidental falls, chest pain, accidental trauma;
  • rarely – irritability.

Overdose

With a single dose up to 800 mg, adverse reactions were comparable to those of sildenafil at lower doses but of more common nature.

In case of overdose, it is demanded to carry out symptomatic therapy. Hemodialysis does not accelerate sildenafil clearance because the latter actively combines with plasma proteins and is not excreted through urine.

Interactions

  • Sildenafil exchange takes place basically through liver under the influence CYP3A4 and CYP2C9 isoenzymes, thereby these isoenzymes inhibitory substance can decrease sildenafil clarification, and inductors, respectively, magnify its clarification.
  • Simultaneous administration with CYP3A4 inhibitors provokes a reduction in sildenafil clarification.
  • Cimetidine (800 mg) in combination with sildenafil (50 mg), which is a nonspecific inhibitor of CYP3A4, becomes the causes of amplification in sildenafil concentration in plasma by 56%.
  • More potent inhibitors of the CYP3A4 isoenzyme, such as ketoconazole or itraconazole, are able to provoke more expressed alterations in Sildenafil pharmacokinetics.
  • When sildenafil (once in a dose of 100 mg) is applied at one and the same time with ritonavir (500 mg 2 times/day), ritonavir concentration in the blood causes an increase in sildenafil Cmax by 300 % (4 times), and AUC by 1000% (11 times).
  • Magnesium hydroxide/Aluminum hydroxide single application does not have any influence on sildenafil bioavailability.
  • Azithromycin application in a dosage of 500 mg/day for 3 days does not affect Sildenafil concentration in blood.

Viagra Generic Name

generic Viagra
The main name of generic is Sildenafil, a preparation named after its main component. Sildenafil is an exclusive analog of the famous brand drug, produced by the same similar technology and composition. At the same time, unlike original medication, Sildenafil is different in lower price, which makes the drug affordable for every man.

How long does Sildenafil Work?

Generic Viagra starts performing within 30 to 60 minutes after taking. After effective relaxation of penile blood vessels, men again gain an opportunity to achieve a full natural erection increasing self-confidence. The active ingredient Sildenafil provokes an increased blood supply to genitals, as a result of which a quality persistent erection lasts much longer. The total duration of Sildenafil effect, which can be bought in Canadian Pharmacy, is up to 5 hours.